The Role of MYB in Prostate Cancer: A Statistical Analysis

Abstract

Prostate cancer (PCa) continues to be a major health issue for men around the world. While treatment advances have improved outcomes for many, aggressive forms of PCa still lead to high mortality rates. Recent research highlights the MYB gene as an important contributor to tumor growth, therapy resistance, and recurrence. What is more, MYB appears to be expressed at significantly higher levels in tumors from Black men compared to White men, suggesting a possible explanation for observed racial disparities in outcomes. This paper examines MYB expression in relation to tumor progression, androgen receptor (AR) activity, and the likelihood of biochemical recurrence. Through a combination of tissue analysis, digital imaging, and public gene expression databases, we show that MYB may be a strong predictor of poor prognosis and could serve as a future target for more personalized treatment strategies.